Side Effects of Oral Acne DrugsOral acne drugs treat the problem from within your body by reducing hormones that boost oil manufacturing. These include anti-biotics such as tetracycline (Tetracin, Tetracap) and minocycline (Solodyn, Minocin) and the pill called spironolactone (Aldactone).Some oral drugs are offered over-the-counter while others nee